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Effects of Formulation and Manufacturing Conditions on Protein Structure and Physical Stability

thesis
posted on 06.11.2019 by Nathan E Wilson
This work focuses on the effects of formulation and manufacturing as it effects protein structure and physical stability. Using common physical characterization techniques, X-ray photoelectron spectroscopy, and solid-state hydrogen/deuterium exchange with mass spectrometry, correlations are identified between these results and accelerated stability studies.

History

Degree Type

Doctor of Philosophy

Department

Industrial and Physical Pharmacy

Campus location

West Lafayette

Advisor/Supervisor/Committee Chair

Qi Tony Zhou

Advisor/Supervisor/Committee co-chair

Elizabeth M. Topp

Additional Committee Member 2

Lynne S. Taylor

Additional Committee Member 3

Suzanne M. D'Addio

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