File(s) under embargo

Reason: Content submitted for publication

59

days

13

hours

until file(s) become available

MASS SPECTROMETRY AT POINT-OF-CARE: SIMPLE YET POWERFUL SOLUTIONS FOR BETTER HEALTH

thesis
posted on 20.11.2019 by Fan Pu

The superior sensitivity and selectivity obtained with mass spectrometry (MS) is hardly matched by other analytical technologies, therefore it is an indispensable tool for modern society. Traditionally, MS is coupled with chromatography separation and performed in centralized analytical laboratories, which often requires extensive sample preparation and expensive instrumentation. With the advancements in the field of ambient MS and miniature MS, MS analysis at point-of-care (POC) has become a reality. Ambient MS includes a variety of methods for sampling and ionization, but they all share a common feature: they require little to no sample preparation. This has made rapid analysis of untreated sample possible and speed of MS analysis is significantly improved. Miniature MS, on the other hand, shrinks down the sizes of conventional benchtop instruments so they become portable or fieldable. In this dissertation, I documented the developments of ambient MS methods and applications of miniature MS for a variety of health-related topics, which include preclinical pharmacokinetics, intraoperative diagnosis, drug adherence monitoring and food safety.

History

Degree Type

Doctor of Philosophy

Department

Chemistry

Campus location

West Lafayette

Advisor/Supervisor/Committee Chair

R. Graham Cooks

Advisor/Supervisor/Committee co-chair

Zheng Ouyang

Additional Committee Member 2

Scott A. McLuckey

Additional Committee Member 3

Jianguo Mei

Licence

Exports

Logo branding

Licence

Exports